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| Name | W | L | SV | ERA | G | GS | IP | HA | R | ER | HR | BB | K | WHIP | OAVG | BABIP | WAR |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sergio Santos RP | 0 | 0 | 0 | 0.00 | 2 | 0 | 2.2 | 0 | 0 | 0 | 0 | 0 | 3 | 0.00 | .000 | .000 | 0.1 |
| Hoyt Wilhelm CL | 8 | 2 | 41 | 1.30 | 61 | 0 | 69.1 | 45 | 10 | 10 | 3 | 17 | 64 | 0.89 | .182 | .231 | 2.7 |
| Bobby Thigpen RP | 2 | 1 | 1 | 2.96 | 21 | 0 | 27.1 | 28 | 11 | 9 | 4 | 10 | 18 | 1.39 | .264 | .282 | -0.1 |
| Wilbur Wood RP | 2 | 4 | 6 | 3.08 | 59 | 0 | 61.1 | 55 | 21 | 21 | 7 | 10 | 54 | 1.06 | .236 | .279 | 0.9 |
| Red Faber SP | 12 | 8 | 0 | 3.27 | 33 | 33 | 228.2 | 227 | 89 | 83 | 16 | 71 | 116 | 1.30 | .263 | .285 | 3.4 |
| Chris Sale SP | 15 | 7 | 0 | 3.46 | 31 | 31 | 205.1 | 185 | 83 | 79 | 29 | 46 | 210 | 1.12 | .239 | .290 | 3.9 |
| Juan Pizarro RP | 4 | 0 | 1 | 3.93 | 29 | 0 | 71.0 | 73 | 34 | 31 | 10 | 18 | 47 | 1.28 | .264 | .285 | -0.1 |
| Jack McDowell SP | 15 | 9 | 0 | 3.94 | 31 | 31 | 196.1 | 192 | 95 | 86 | 23 | 70 | 185 | 1.33 | .256 | .309 | 3.3 |
| Ed Walsh SP | 15 | 10 | 0 | 4.11 | 33 | 33 | 234.1 | 261 | 114 | 107 | 16 | 78 | 126 | 1.45 | .282 | .309 | 3.7 |
| Eddie Cicotte SP | 14 | 13 | 0 | 4.56 | 33 | 33 | 219.0 | 249 | 126 | 111 | 18 | 75 | 115 | 1.48 | .288 | .312 | 2.8 |
| Keith Foulke RP | 4 | 10 | 2 | 4.83 | 42 | 0 | 54.0 | 64 | 34 | 29 | 9 | 13 | 43 | 1.43 | .295 | .327 | -0.0 |
| Matt Thornton RP | 1 | 0 | 1 | 5.48 | 19 | 0 | 21.1 | 24 | 13 | 13 | 4 | 10 | 20 | 1.59 | .289 | .339 | -0.2 |
| Scott Radinsky RP | 0 | 1 | 1 | 6.00 | 12 | 0 | 12.0 | 12 | 10 | 8 | 3 | 7 | 12 | 1.58 | .250 | .273 | -0.2 |
| Bob Locker RP | 2 | 0 | 0 | 6.44 | 20 | 0 | 29.1 | 35 | 21 | 21 | 5 | 13 | 19 | 1.64 | .304 | .323 | -0.3 |
| Terry Forster RP | 0 | 0 | 0 | 6.75 | 3 | 0 | 4.0 | 4 | 3 | 3 | 1 | 2 | 4 | 1.50 | .250 | .273 | -0.1 |
| Mark Buehrle RP | 1 | 0 | 0 | 6.75 | 6 | 0 | 9.1 | 18 | 7 | 7 | 1 | 1 | 11 | 2.04 | .400 | .515 | 0.2 |
| Bobby Jenks RP | 0 | 1 | 0 | 22.50 | 2 | 0 | 2.0 | 4 | 5 | 5 | 0 | 2 | 2 | 3.00 | .444 | .571 | 0.0 |
| Doc White RP | 0 | 0 | 0 | 23.14 | 3 | 0 | 2.1 | 5 | 6 | 6 | 1 | 3 | 1 | 3.43 | .417 | .400 | -0.2 |
