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| Name | W | L | SV | ERA | G | GS | IP | HA | R | ER | HR | BB | K | WHIP | OAVG | BABIP | WAR |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dick Drago RP | 4 | 3 | 0 | 2.73 | 46 | 0 | 59.1 | 53 | 21 | 18 | 7 | 24 | 59 | 1.30 | .239 | .289 | 0.4 |
| Tom Gordon RP | 4 | 4 | 4 | 3.32 | 69 | 0 | 59.2 | 53 | 23 | 22 | 4 | 21 | 49 | 1.24 | .235 | .283 | 0.9 |
| Smoky Joe Wood SP | 16 | 12 | 0 | 3.50 | 37 | 37 | 239.1 | 239 | 109 | 93 | 17 | 95 | 187 | 1.40 | .260 | .308 | 3.7 |
| Jonathan Papelbon CL | 3 | 3 | 35 | 4.03 | 54 | 0 | 51.1 | 49 | 25 | 23 | 7 | 12 | 61 | 1.19 | .244 | .316 | 0.9 |
| Cy Young SP | 12 | 16 | 0 | 4.34 | 38 | 38 | 228.1 | 284 | 121 | 110 | 18 | 48 | 90 | 1.45 | .307 | .320 | 2.6 |
| Dutch H Leonard SP | 7 | 9 | 0 | 4.48 | 22 | 22 | 120.2 | 134 | 73 | 60 | 6 | 55 | 102 | 1.57 | .285 | .352 | 2.2 |
| Jon Lester RP | 3 | 5 | 0 | 4.53 | 37 | 9 | 111.1 | 123 | 57 | 56 | 18 | 44 | 120 | 1.50 | .276 | .339 | 0.5 |
| Roger Clemens SP | 15 | 13 | 0 | 4.68 | 38 | 38 | 230.2 | 245 | 134 | 120 | 33 | 78 | 231 | 1.40 | .268 | .324 | 2.9 |
| Tom Burgmeier RP | 0 | 1 | 1 | 5.34 | 41 | 0 | 55.2 | 69 | 38 | 33 | 7 | 10 | 25 | 1.42 | .301 | .310 | -0.2 |
| Daniel Bard RP | 2 | 4 | 0 | 5.50 | 43 | 0 | 52.1 | 63 | 38 | 32 | 3 | 21 | 50 | 1.61 | .293 | .366 | 0.8 |
| Dick Radatz RP | 7 | 5 | 3 | 5.52 | 49 | 0 | 58.2 | 65 | 38 | 36 | 12 | 20 | 49 | 1.45 | .279 | .305 | -0.7 |
| Luis Tiant RP | 4 | 9 | 0 | 5.73 | 45 | 17 | 150.2 | 167 | 102 | 96 | 20 | 69 | 127 | 1.57 | .283 | .327 | 0.4 |
