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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Player | From-To | Avg | HR | RBI | W | L | SV | ERA | K |
|---|---|---|---|---|---|---|---|---|---|
| Pete M O'Brien | 2015-2015 | .750 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0 |
| Darren O'Day | 2014-2016 | .000 | 0 | 0 | 9 | 5 | 9 | 5.33 | 114 |
| Lefty O'Doul | 2014-2016 | .295 | 59 | 268 | 0 | 0 | 0 | 0.00 | 0 |
| Paul O'Neill | 2014-2016 | .262 | 30 | 156 | 0 | 0 | 0 | 0.00 | 0 |
| Steve O'Neill | 2014-2016 | .256 | 1 | 39 | 0 | 0 | 0 | 0.00 | 0 |
| Mike Oakley | 2015-2016 | .270 | 27 | 98 | 0 | 0 | 0 | 0.00 | 0 |
| Blue Moon Odom | 2014-2014 | .000 | 0 | 0 | 0 | 1 | 0 | 4.61 | 9 |
| Jose Offerman | 2014-2016 | .248 | 8 | 58 | 0 | 0 | 0 | 0.00 | 0 |
| Alexi Ogando | 2014-2016 | .000 | 0 | 0 | 7 | 8 | 2 | 5.06 | 169 |
| Ben Oglivie | 2014-2015 | .000 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0 |
| John Olerud | 2014-2016 | .280 | 47 | 189 | 0 | 0 | 0 | 0.00 | 0 |
| Tony Oliva | 2014-2016 | .273 | 50 | 224 | 0 | 0 | 0 | 0.00 | 0 |
| Al Oliver | 2014-2016 | .276 | 0 | 7 | 0 | 0 | 0 | 0.00 | 0 |
| Gregg Olson | 2014-2016 | .000 | 0 | 0 | 1 | 0 | 1 | 4.02 | 49 |
| Magglio Ordonez | 2014-2016 | .260 | 17 | 73 | 0 | 0 | 0 | 0.00 | 0 |
| Jorge Orta | 2014-2016 | .277 | 3 | 20 | 0 | 0 | 0 | 0.00 | 0 |
| David Ortiz | 2014-2016 | .244 | 54 | 169 | 0 | 0 | 0 | 0.00 | 0 |
| Roy Oswalt | 2014-2016 | .000 | 0 | 0 | 8 | 1 | 0 | 3.73 | 202 |
| Amos Otis | 2014-2016 | .265 | 13 | 46 | 0 | 0 | 0 | 0.00 | 0 |
| Akinori Otsuka | 2014-2016 | .000 | 0 | 0 | 14 | 6 | 6 | 3.39 | 136 |
| Mel Ott | 2014-2016 | .269 | 44 | 208 | 0 | 0 | 0 | 0.00 | 0 |
| Juan Carlos Oviedo | 2014-2016 | .000 | 0 | 0 | 4 | 0 | 1 | 2.72 | 47 |
| Spike Owen | 2014-2016 | .242 | 20 | 102 | 0 | 0 | 0 | 0.00 | 0 |
